TB - Risk Conditions

Conditions that Increase the Risk of Progression to TB Disease

These are conditions proven to increase the risk of activating TB infection. This list indicates that potentially any condition associated with a weakened immune system could increase your chances of a latent TB infection progressing to active TB disease. If you have a good immune system, your chances of your latent TB infection activating is 10% over a lifetime. Currently, there are studies underway investigating other conditions which may activate latent TB infection (ie. tobacco use).

  • HIV Infection (7 - 10% chance every year)
  • Substance Abuse
  • Recent TB Infection
  • Chest X-Ray suggestive of previously active TB disease
  • Diabetes mellitus (30% chance over life)
  • Silicosis
  • Prolonged Corticosteriod Use
  • Any Immune System Suppressive Therapy
      (ie. Organ transplant drugs; Rheumatoid arthritis drug: Remicade (Infliximab))
  • Cancer of Head or Neck
  • Hematological or Reticuloendothelial diseases (ie. leukemia or Hodgkin's disease)
  • End-stage Renal (kidney) disease
  • Intestinal bypass or gastectomy
  • Chronic malabsorption syndromes
  • Low Body Weight (10% or more below ideal body weight)